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pentobarbital will lessen the extent or impact of midostaurin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Solid CYP3A4 inducers could lessen midostaurin concentrations resulting in lessened efficacy.pentobarbital will lessen the extent or impact of bortezomib by impacting hepatic/intestinal enzy